Ming-Hai Wang Selected Research

Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)

12/2020	Progress and challenge in development of biotherapeutics targeting MET receptor for treatment of advanced cancer.
11/2020	Pathological significance of abnormal recepteur d'origine nantais and programmed death ligand 1 expression in colorectal cancer.
1/2020	RON receptor tyrosine kinase in pancreatic ductal adenocarcinoma: Pathogenic mechanism in malignancy and pharmaceutical target for therapy.
1/2020	Targeting RON receptor tyrosine kinase for treatment of advanced solid cancers: antibody-drug conjugates as lead drug candidates for clinical trials.
1/2020	Antibody-drug conjugates targeting RON receptor tyrosine kinase as a novel strategy for treatment of triple-negative breast cancer.
4/2019	Correction to: Therapeutic efficacy, pharmacokinetic profiles, and toxicological activities of humanized antibody-drug conjugate Zt/g4-MMAE targeting RON receptor tyrosine kinase for cancer therapy.
1/2019	Therapeutic efficacy, pharmacokinetic profiles, and toxicological activities of humanized antibody-drug conjugate Zt/g4-MMAE targeting RON receptor tyrosine kinase for cancer therapy.
12/2018	RON Receptor Tyrosine Kinase as a Therapeutic Target for Eradication of Triple-Negative Breast Cancer: Efficacy of Anti-RON ADC Zt/g4-MMAE.
1/2018	Preclinical Efficacy of Anti-RON Antibody-Drug Conjugate Zt/g4-MMAE for Targeted Therapy of Pancreatic Cancer Overexpressing RON Receptor Tyrosine Kinase.
4/2016	Biological evaluation of antibody-maytansinoid conjugates as a strategy of RON targeted drug delivery for treatment of non-small cell lung cancer.

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Ming-Hai Wang Research Topics

Disease

49	Neoplasms (Cancer) 01/2022 - 09/2002
11	Carcinogenesis 12/2020 - 11/2004
10	Breast Neoplasms (Breast Cancer) 04/2016 - 03/2008
9	Pancreatic Neoplasms (Pancreatic Cancer) 01/2019 - 05/2011
4	Colorectal Neoplasms (Colorectal Cancer) 11/2020 - 11/2004
3	Adenocarcinoma 09/2020 - 01/2003
3	Triple Negative Breast Neoplasms 07/2020 - 12/2018
3	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 06/2016 - 12/2015
3	Polyploidy 05/2014 - 05/2013
3	Neoplasm Metastasis (Metastasis) 12/2012 - 03/2004
3	Colonic Neoplasms (Colon Cancer) 07/2011 - 08/2010
2	Stomach Neoplasms (Stomach Cancer) 10/2020 - 01/2020
1	Body Weight (Weight, Body) 01/2022
1	Lung Neoplasms (Lung Cancer) 12/2015
1	Hepatitis 01/2015
1	Hepatocellular Carcinoma (Hepatoma) 01/2015
1	Retinoblastoma (Glioblastoma, Retinal) 05/2014
1	Leukemia 09/2013
1	Lymphatic Metastasis 12/2012
1	Breast Diseases (Breast Disease) 12/2012

Drug/Important Bio-Agent (IBA)

30	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 12/2020 - 09/2002
16	Pharmaceutical PreparationsIBA 01/2022 - 05/2011
12	Immunoconjugates (Immunoconjugate)IBA 01/2022 - 01/2015
9	Monoclonal AntibodiesIBA 04/2016 - 06/2006
6	RON proteinIBA 11/2020 - 11/2002
6	Biological ProductsIBA 01/2019 - 09/2002
5	Tyrosine Kinase InhibitorsIBA 07/2020 - 05/2013
5	N- (4- (2- amino- 3- chloropyridin- 4- yloxy)- 3- fluorophenyl)- 4- ethoxy- 1- (4- fluorophenyl)- 2- oxo- 1,2- dihydropyridine- 3- carboxamideIBA 07/2020 - 05/2013
5	Small Interfering RNA (siRNA)IBA 05/2013 - 11/2004
4	Proteins (Proteins, Gene)FDA Link 10/2020 - 11/2004
4	tyrosine receptor (receptor, tyrosine)IBA 09/2020 - 11/2004
4	Phosphotransferases (Kinase)IBA 09/2020 - 11/2004
3	Biomarkers (Surrogate Marker)IBA 10/2020 - 12/2015
3	Messenger RNA (mRNA)IBA 10/2020 - 12/2012
3	RNA (Ribonucleic Acid)IBA 10/2020 - 11/2004
3	AntibodiesIBA 01/2019 - 08/2010
3	Therapeutic UsesIBA 10/2014 - 01/2012
2	Proto-Oncogene Proteins c-metIBA 01/2022 - 01/2021
2	Dihydrotachysterol (AT 10)IBA 01/2022 - 12/2018
2	capmatinibIBA 07/2020 - 01/2019
2	ARQ 197IBA 07/2020 - 01/2019
2	5- ((2,6- dichlorobenzyl)sulfonyl)- 3- ((3,5- dimethyl- 4- ((2- (pyrrolidin- 1- ylmethyl)pyrrolidin- 1- yl)carbonyl)- 1H- pyrrol- 2- yl)methylene)- 1,3- dihydro- 2H- indol- 2- oneIBA 01/2019 - 07/2013
2	6- methoxy- 1- (naphthalen- 1- yl)- 9H- pyrido(3,4- b)indoleIBA 05/2015 - 10/2014
2	(5- (2,4- bis((3S)- 3- methylmorpholin- 4- yl)pyrido(2,3- d)pyrimidin- 7- yl)- 2- methoxyphenyl)methanolIBA 05/2014 - 01/2014
2	Aurora Kinase BIBA 01/2014 - 05/2013
2	LigandsIBA 07/2013 - 06/2010
2	Hepatocyte Growth Factor (Growth Factor, Hepatocyte)IBA 07/2013 - 09/2010
2	macrophage stimulating proteinIBA 07/2013 - 06/2010
2	GinsenosidesIBA 01/2012 - 01/2012
2	Doxorubicin (Adriamycin)FDA LinkGeneric 05/2011 - 04/2010
2	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 11/2007 - 07/2007
2	beta CateninIBA 07/2005 - 11/2004
1	DuocarmycinsIBA 01/2021
1	Bispecific AntibodiesIBA 12/2020
1	Staphylococcal Protein A (Protein A)IBA 12/2020
1	B7-H1 AntigenIBA 11/2020
1	N-methyladenosineIBA 10/2020
1	LuciferasesIBA 10/2020
1	MethyltransferasesIBA 01/2020
1	Cytotoxins (Cytolysins)IBA 01/2020
1	plexinIBA 01/2019
1	IntegrinsIBA 01/2019
1	Semaphorins (Semaphorin)IBA 01/2019
1	Membrane Proteins (Integral Membrane Proteins)IBA 01/2018
1	Sulfides (Thioethers)IBA 04/2016
1	Gemcitabine FDA Link 01/2016
1	CateninsIBA 01/2015
1	TCF Transcription FactorsIBA 01/2015
1	Maytansine (Maitansine)IBA 12/2014
1	indoleIBA 10/2014
1	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 10/2014
1	sepantroniumIBA 05/2014
1	DNA (Deoxyribonucleic Acid)IBA 05/2014
1	SurvivinIBA 05/2014
1	A-Form DNA (A-DNA)IBA 05/2014
1	GalactosidasesIBA 05/2014
1	Oncogene Proteins (Oncogene Protein)IBA 09/2013
1	7- (benzylamino)- 1,3,4,8- tetrahydropyrrolo(4,3,2- de)quinolin- 8(1H)- oneIBA 07/2013
1	iminoquinoneIBA 07/2013
1	TubulinIBA 05/2013
1	Vascular Endothelial Growth Factor Receptor-3 (Flt 4)IBA 12/2012
1	Vascular Endothelial Growth Factor CIBA 12/2012
1	Vascular Endothelial Growth Factor DIBA 12/2012
1	7- (4- fluorobenzylamino)- 1,3,4,8- tetrahydropyrrolo(4,3,2- de)quinolin- 8(1H)- oneIBA 05/2012
1	CyclinsIBA 01/2012
1	25-methoxylprotopanaxadiolIBA 01/2012
1	SulfonamidesIBA 01/2012
1	Antineoplastic Agents (Antineoplastics)IBA 01/2012
1	CaspasesIBA 01/2012
1	AMP-Activated Protein KinasesIBA 01/2012
1	Death Domain ReceptorsIBA 01/2012
1	Harmine (Telepathine)IBA 01/2012
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2012
1	Protein Kinases (Protein Kinase)IBA 01/2012
1	SaponinsIBA 01/2012

Therapy/Procedure

26	Therapeutics 01/2022 - 09/2010
2	Drug Therapy (Chemotherapy) 12/2015 - 05/2013
1	Aftercare (After-Treatment) 01/2022
1	Immunotherapy 11/2020
1	Intraperitoneal Injections 10/2014